Album was composed by Ennio Morricone and was released on February 28, 2012. Soundtrack consists of 38 tracks tracks with duration over . Album was released by C.R.
CD 1
| 1 | Main Theme (from C'Era una Volta in America / Once Upon a Time in America) | |  |
| 2 | Cockeye's Song (from C'era una volta in America / Once Upon a Time in America) | | |
| 3 | Il Etait une Fois La revolution (from Giù la Testa / Duck, You Sucker / A Fistful of Dynamite) | | |
| 4 | Il Bueno, il Bruto, il Cattivo (from Il Bueno, il Brutto, il Cattivo / The Good, the Bad and the Ugly) | | |
| 5 | Once Upon a Time in the West (from C'Era una Volta il West / Once Upon a Time in the West) | | |
| 6 | The Man with the Harmonica (from C'Era una Volta il West / Once Upon a Time in the West) | | |
| 7 | Apres l'Explosion (from C'Era una Volta il West / Once Upon a Time in the West) | | |
| 8 | First Theme (from Per un Pugno di Dollari / A Fistful of Dollars) | | |
| 9 | Second Theme (from Per un Pugno di Dollari / A Fistful of Dollars) | | |
| 10 | Square Dance (from Per un Pugno di Dollari / A Fistful of Dollars) | | |
| 11 | Per Qualche Dollari in Piú (from Per Qualche Dollaro in Piú / For a Few Dollars More) | | |
| 12 | Bye Bye Colonel (from Per Qualche Dollaro in Piú / For a Few Dollars More) | | |
| 13 | Sixty Seconds to What (from Per Qualche Dollaro in Piú / For a Few Dollars More) | | |
| 14 | Il Mio Nome é Nessuno (from Il Mio Nome É Nessuno / My Name Is Nobody) | | |
| 15 | El Mercenario (from Il mercenario / The Mercenary / A Professional Gun) | | |
| 16 | A Gun for Ringo (from Una Pistola per Ringo / A Gun for Ringo) | | |
| 17 | La Libertad (from l'Alibi / Alibi) | | |
| 18 | The Ballad of "Sacco e Vanzetti" (from Sacco e Vanzetti) | | |
| 19 | Here's to You (from Sacco e Vanzetti) | | |
| 20 | The Heretic (from Exorcist II) | | |
| 21 | Love Theme (from Nuovo Cinema Paradiso / Cinema Paradiso) | | |
| 22 | Playing Love (from La Leggenda del Pianista Sull Oceano / The Legend of 1900) | | |
| 23 | Goodbye Duet (from La Leggenda del Pianista Sull Oceano / The Legend of 1900) | | |
| 24 | Nineteen Hundred's Madness (from La Leggenda del Pianista Sull Oceano / The Legend of 1900) | | |
| 25 | L'Alba Verra' (from Aida degli Alberi / Aida of the Trees) | | |
| 26 | Mission (from Mission / The Mission) | | |
| 27 | Metti, una Sera a Cena (from Metti, una Sera a Cena / One Night at Dinner / Love Circle) | | |
| 28 | Tepepa (from Tepepa / Blood and Guns / Long Live the Revolution) | | |
| 29 | Visioni - Fantasie d'Amore (from Malena) | | |
| 30 | Il Maestro e Margherita (from Il Maestro e Margherita / The Master and Margaret) | | |
| 31 | Il Clan dei Siciliani (from Le clan des Siciliens / The Sicilian Clan) | | |
| 32 | Incontro (from Incontro) | | |
| 33 | Chi Mai (from Maddalena) | | |
| 34 | Dio E' con Noi (from Dio E' con Noi / 5th Day of Peace) | | |
| 35 | Metello (from Metello) | | |
| 36 | La Califfa (from La Califfa / Lady Caliph) | | |
| 37 | Ninna Nanna in Blu (from La Califfa / Lady Caliph) | | |
| 38 | Indagine (from Indagine Su un Cittadino al di Sopra di Ogni Sospetto / Investigation of a Citizen Above Suspicion) | | |
