Album was composed by John Debney and was released on October 22, 2012. Soundtrack consists of 24 tracks tracks with duration over more than hour. Album was released by Metropolis Movie Music Ltd.
CD 1
| 1 | Alex Cross OpeningJohn Debney | 01:41 |  |
| 2 | Going to Pop PopJohn Debney | 01:17 | |
| 3 | Maria Is PregnantJohn Debney | 02:14 | |
| 4 | MMA EnteranceJohn Debney | 01:33 | |
| 5 | Picasso Breaks an ArmJohn Debney | 00:52 | |
| 6 | Picasso Seduces WomenJohn Debney | 03:04 | |
| 7 | Tommy / Monica TalkJohn Debney | 02:04 | |
| 8 | Alex Accesses Crime SceneJohn Debney | 04:45 | |
| 9 | Next TargetJohn Debney | 01:01 | |
| 10 | Aqua BuildingJohn Debney | 06:20 | |
| 11 | Boom He's GoneJohn Debney | 01:55 | |
| 12 | Alex Profiles KillerJohn Debney | 01:37 | |
| 13 | I Don't Want to DieJohn Debney | 01:58 | |
| 14 | Picasso Kills MariaJohn Debney | 05:11 | |
| 15 | Alex Comforts JanelleJohn Debney | 02:57 | |
| 16 | Detroit P.D. BreakinJohn Debney | 01:55 | |
| 17 | Give Me a NameJohn Debney | 02:00 | |
| 18 | Shutdown Courthouse SquareJohn Debney | 02:54 | |
| 19 | Picasso Takes TrainJohn Debney | 05:40 | |
| 20 | Confronting PicassoJohn Debney | 02:48 | |
| 21 | Alex / Picasso Do BattleJohn Debney | 02:38 | |
| 22 | It Ain't Over TommyJohn Debney | 02:02 | |
| 23 | Restrained SatisfactionJohn Debney | 01:48 | |
| 24 | Alex Walks to HouseJohn Debney | 01:10 | |
