Album was composed by and was released on September 20, 2005. Soundtrack consists of 21 tracks tracks with duration over about 50 minutes. Album was released by Touchstone Television.
CD 1
| 1 | Mary Alice (Spoken Word Intro)Mary Alice | 00:48 |  |
| 2 | God Bless the American HousewifeSHeDAISY | 03:43 | |
| 3 | Edie (Spoken Word Version)Edie | 00:04 | |
| 4 | ShoesShania Twain | 03:55 | |
| 5 | Band of GoldAnna Nalick | 03:11 | |
| 6 | Lynette (Spoken Word Version)Lynette | 00:13 | |
| 7 | Mother's Little HelperLiz Phair | 03:02 | |
| 8 | Mrs. RobinsonIndigo Girls | 03:46 | |
| 9 | Harper Valley PTAMartina McBride | 03:26 | |
| 10 | Bree (Spoken Word Version)Bree | 00:06 | |
| 11 | We're Running Out of TimeLeAnn Rimes | 04:07 | |
| 12 | Treat Me Right (I'm Yours for Life)Joss Stone | 04:01 | |
| 13 | One's On the WaySara Evans | 03:22 | |
| 14 | Gabrielle (Spoken Word Version)Gabrielle | 00:04 | |
| 15 | Boom BoomMacy Gray | 02:40 | |
| 16 | Young Hearts Run FreeGloria Estefan | 03:45 | |
| 17 | Susan (Spoken Word Version)Susan | 00:06 | |
| 18 | Damsel In DistressIdina Menzel | 03:08 | |
| 19 | Dream of the Everyday Housewifek.d. lang | 03:53 | |
| 20 | Mary Alice (Spoken Word Outro)Mary Alice | 00:12 | |
| 21 | Desperate Housewives ThemeDanny Elfman | 00:40 | |
