Album was composed by Ennio Morricone and was released on March 01, 2011. Soundtrack consists of 19 tracks tracks with duration over more than hour. Album was released by Kind of Blue Records.
CD 1
| 1 | Once Upon A Time In America - TitlesEnnio Morricone | 02:12 |  |
| 2 | PovertyEnnio Morricone | 03:38 | |
| 3 | Deborah's ThemeEnnio Morricone | 04:24 | |
| 4 | Childhood Memories (Pan Flute)Ennio Morricone | 03:26 | |
| 5 | AmapolaEnnio Morricone | 05:23 | |
| 6 | FriendsEnnio Morricone | 01:37 | |
| 7 | Prohibition DirgeEnnio Morricone | 04:23 | |
| 8 | Cockeye's SongEnnio Morricone | 04:21 | |
| 9 | Amapola Part IIEnnio Morricone | 03:09 | |
| 10 | Childhood PovertyEnnio Morricone | 01:43 | |
| 11 | Photographic MemoriesEnnio Morricone | 01:03 | |
| 12 | FriendsEnnio Morricone | 01:24 | |
| 13 | Friendship and LoveEnnio Morricone | 04:15 | |
| 14 | SpeakeasyEnnio Morricone | 02:23 | |
| 15 | Deborah's Theme / AmapolaEnnio Morricone | 06:16 | |
| 16 | Suite From Once Upon A Time In AmericaEnnio Morricone | 13:33 | |
| 17 | Poverty (Temp. Version)Ennio Morricone | 03:28 | |
| 18 | Unused ThemeEnnio Morricone | 04:49 | |
| 19 | Unused Theme (Version II)Ennio Morricone | 03:40 | |
